Savillex Technical Note: CO2 Ingress Testing on Purillex PETG Square Media Bottles

Carbon dioxide (CO2) ingress into polymeric containers can be an issue when storing or shipping pH-sensitive drug products, biologics, and other critical liquid materials. When storing or shipping these products, they can be packed in dry ice, which is the solid form of CO2.

Dry ice does not melt into a liquid, but rather sublimates from a solid to a gas, which has the potential to enter the container either through the bulk of the material or through the container/closure interface. If there is headspace in the container and CO2 gas enters, it has the potential to adversely affect the container contents by lowering the pH due to the formation of carbonic acid with container contents.

Testing was performed to determine if a pH shift could be measured in 1L Savillex Purillex PETG Square Media Bottles (both sterile and non-sterile) filled to nominal volume with phosphate buffered saline (PBS) after exposure to dry ice for a minimum of 60 hours. Fill out the brief form to view and download the associated technical note!